Lead/Drug Discovery from Natural Resources

Lead/Drug Discovery from Natural Resources

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Natural tiny gum squares products and their derivatives have been shown to be effective drug candidates against various diseases for many years.Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures.Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents.This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or lead compounds mainly discovered from 2016 to 2022.

Structurally typical marine bioactive products are also included.Molecular modeling, machine learning, bioinformatics and other computer-assisted techniques that are very important in tommy todd ointment narrowing down bioactive core structural scaffolds and helping to design new structures to fight against key disease-associated molecular targets based on available natural products are considered and briefly reviewed.